Constructing topological models by symmetrization: A PEPS study

Symmetrization of topologically ordered wavefunctions is a powerful method for constructing new topological models. Here, we study wavefunctions obtained by symmetrizing quantum double models of a group $G$ in the Projected Entangled Pair States (PEPS) formalism. We show that symmetrization naturally gives rise to a larger symmetry group $\tilde G$ which is always non-abelian. We prove that by symmetrizing on sufficiently large blocks, one can always construct wavefunctions in the same phase as the double model of $\tilde G$. In order to understand the effect of symmetrization on smaller patches, we carry out numerical studies for the toric code model, where we find strong evidence that symmetrizing on individual spins gives rise to a critical model which is at the phase transitions of two inequivalent toric codes, obtained by anyon condensation from the double model of $\tilde G$.Comment: 10 pages. v2: accepted versio

Multicarrier Waveform Harmonization and Complexity Analysis for an Efficient 5G Air Interface Implementation

[EN] The coexistence of multiple air interface variants in the upcoming fifth generation (5G) wireless technology remains a matter of ongoing discussion. This paper focuses on the physical layer of the 5G air interface and provides a harmonization solution for the joint implementation of several multicarrier waveform candidates. Waveforms based either on cyclic prefix-orthogonal frequency division multiplexing (CP-OFDM) or on filter bank multicarrier (FBMC) are first presented through a harmonized system model. Complexity comparisons among five different waveforms are provided. Then, the complexity of a proposed configurable hardware implementation setup for waveform transmission and reception is evaluated. As a result, the harmonized transmitter and receiver exhibit 25¿40% and 15¿25% less complexity in floating-point operations, respectively, in comparison to two standalone implementations of the most complex waveform instances of the CP-OFDM and FBMC families. This highlights the similarities between both families and illustrates the component reuse advantages associated with the proposed harmonized solution.This work was performed in the framework of the H2020 Project METIS-II with reference 671680, which is partly funded by the European Union. The authors would like to acknowledge the contributions of their colleagues in METIS-II. This work was also supported in part by the Ministerio de Economia y Competitividad, under Grant TEC2014-60258-C2-1-R.Garcia-Roger, D.; Roger Varea, S.; Flores De Valgas, J.; Monserrat, JF. (2017). Multicarrier Waveform Harmonization and Complexity Analysis for an Efficient 5G Air Interface Implementation. Wireless Communications and Mobile Computing. 2017:1-11. https://doi.org/10.1155/2017/9765614S111201

Low-Latency Infrastructure-Based Cellular V2V Communications for Multi-Operator Environments With Regional Split

[EN] Mobile network operators are interested in providing Vehicle-to-Vehicle (V2V) communication services using their cellular infrastructure. Regional split of operators is one possible approach to support multi-operator infrastructure-based cellular V2V communication. In this approach, a geographical area is divided into non-overlapping regions, each one served by a unique operator. Its main drawback is the communication interruption motivated by the inter-operator handover in border areas, which prevents the fulfillment of the maximum end-to-end (E2E) latency requirements of fifth generation (5G) V2V services related to autonomous driving. In this work, we enable a fast inter-operator handover based on the pre-registration of the users on multiple operators, which substantially reduces the handover time to guarantee maximum E2E latency values of 100 ms in non-congested scenarios. To further reduce the latency of time-critical services to always less than 70 ms, even with the handover interruption time, while providing a latency around 20 ms in the majority of locations, we propose to complement the former technique with a mobile edge computing approach. Our proposal consists in the localization of application servers and broadcasting entities in all the base stations, to avoid the communication through the core network, together with the use of a new set of nodes in the base stations of cross-border areas called inter-operator relays, to minimize the communication latency between operators. Based on analytic and simulation results, it is demonstrated that the proposed techniques are effective to support low-latency infrastructure-based cellular V2V communications in multi-operator environments with regional split.The work of S. Roger was partially supported by the Spanish Ministry of Science, Innovation and Universities through grant number RYC-2017-22101.Martín-Sacristán, D.; Roger, S.; Garcia-Roger, D.; Monserrat Del Río, JF.; Spapis, P.; Zhou, C.; Kaloxylos, A. (2021). Low-Latency Infrastructure-Based Cellular V2V Communications for Multi-Operator Environments With Regional Split. IEEE Transactions on Intelligent Transportation Systems. 22(2):1052-1067. https://doi.org/10.1109/TITS.2019.29620971052106722

LTE/NR V2X Communication Modes and Future Requirements of Intelligent Transportation Systems Based on MR-DC Architectures

[EN] This paper deals with the potential of Third Generation Partnership (3GPP) Project mobile cellular standards to enable vehicular communications. Starting from 3GPP Release 15, and Release 16 specifications for Vehicle-to-Everything (V2X) communications, the different communication modes, interfaces and use cases for V2X based on Long Term Evolution (LTE) and New Radio (NR) are analyzed. This research also studies the potential beneficial impact on V2X of a network that is aware of the underlying Multi-RAT Dual Connectivity (MR-DC) architecture. The methodology followed in this work consists of a review of 3GPP standards for vehicular communications based on mobile networks. The performance evaluation of the communication modes was performed through simulations taking into account resource allocation schemes, packet transmission frequencies, packet size, vehicle density and other parameters defined in the standard. In order to perform simulations of the decentralized communication mode (mode 4), a simulator based on OMNeT++ was configured. For the centralized mode (mode 3), an analytical model in MATLAB was used to configure different simulation scenarios. The results obtained indicate that LTE networks can only support basic V2X use cases because they do not demand strict potential requirements. Simulations showed that the centralized mode offers better performance than mode 4; however, it requires cellular network coverage. More advanced use cases are key for a future Intelligent Transport System (ITS), high-performance networks (i.e., Fifth Generation (5G), NR) are expected to coexist gradually with LTE in the V2X landscape. Therefore, in order to meet the strict requirements for latency, transmission speed and reliability, MR-DC architectures combining different radio access technologies, communication modes and connection interfaces should be deployed. In addition, operation in multi-operator and cross-border scenarios must be guaranteed.This research was supported by the European Union's H2020-ICT-18-2018 action "5G for cooperative, connected and automated mobility", for project "5G for Connected and Automated Road Mobility in the European unioN (5G-CARMEN)" under grant agreement no. 825012.González, EE.; Garcia-Roger, D.; Monserrat Del Río, JF. (2022). LTE/NR V2X Communication Modes and Future Requirements of Intelligent Transportation Systems Based on MR-DC Architectures. Sustainability. 14(7):1-19. https://doi.org/10.3390/su1407387911914

Multi-Objective Routing Optimization for 6G Communication Networks Using a Quantum Approximate Optimization Algorithm

[EN] Sixth-generation wireless (6G) technology has been focused on in the wireless research community. Global coverage, massive spectrum usage, complex new applications, and strong security are among the new paradigms introduced by 6G. However, realizing such features may require computation capabilities transcending those of present (classical) computers. Large technology companies are already exploring quantum computers, which could be adopted as potential technological enablers for 6G. This is a promising avenue to explore because quantum computers exploit the properties of quantum states to perform certain computations significantly faster than classical computers. This paper focuses on routing optimization in wireless mesh networks using quantum computers, explicitly applying the quantum approximate optimization algorithm (QAOA). Single-objective and multi-objective examples are presented as robust candidates for the application of quantum machine learning. Moreover, a discussion about quantum supremacy estimation for this problem is provided.Urgelles-Pérez, H.; Picazo-Martínez, P.; Garcia-Roger, D.; Monserrat Del Río, JF. (2022). Multi-Objective Routing Optimization for 6G Communication Networks Using a Quantum Approximate Optimization Algorithm. Sensors. 22(19):1-14. https://doi.org/10.3390/s22197570114221

A role for the spindle assembly checkpoint in the DNA damage response

Spontaneous DNA damage poses a continuous threat to genomic integrity. If unchecked, genotoxic insults result in genomic instability, a hallmark of cancer cells. In eukaryotic cells a DNA Damage Response (DDR) detects and responds to genotoxic stress, acting as an anti-cancer barrier in humans. Among other actions, the DDR blocks the segregation of incompletely replicated or damaged chromosomes, thus preventing aneuploidy. In a work aimed at better understanding such S-M control, we recently showed that cells block anaphase through different control pathways. The S phase checkpoint kinase Mec1/ATR inhibits mitotic Cyclin Dependent Kinase activity through effector kinases Swe1/Wee1 and Rad53/Chk2. Cells also stabilize the levels of Pds1/securin to block sister chromatid segregation in response to DNA damage. We show here that Pds1/securin abundance is still secured when the S phase checkpoint response is fully abrogated in mec1/ATR tel1/ATM double null mutants. When such cells are exposed to genotoxic stress, Pds1/securin is stabilized in a spindle assembly checkpoint (SAC) dependent manner. Disruption of the SAC and the S phase checkpoint together, allows chromosome segregation in the presence of DNA damage or replication stress. Our results place the SAC as a part of the DDR, which appears to count on different, independent control layers to preserve genomic integrity when chromosome replication is challenged

Implementation of a multiprofessional, multicomponent delirium management guideline in two intensive care units, and its effect on patient outcomes and nurse workload: a pre-post design retrospective cohort study.

AIM OF THE STUDY Delirium is a frequent intensive care unit (ICU) complication, affecting 26% to 80% of ICU patients, often with serious consequences. This study aimed to evaluate the effectiveness, costs and benefits of following a standardised multiprofessional, multicomponent delirium guideline on eight outcomes: delirium prevalence and duration, lengths of stay in ICU and hospital, in-hospital mortality, duration of mechanical ventilation, and cost and nursing hours per case. It also aimed to explore the associations of delirium with length of ICU stay, length of hospital stay and duration of mechanical ventilation. METHODS This retrospective cohort study used a pre-post design. ICU patients in an historical control group (n = 1608) who received standard ICU care were compared with a postintervention group (n = 1684) who received standardised delirium management – delirium risk identification, preventive measures, screening and treatment – with regard to eight outcomes. The delirium management guideline was developed and implemented in 2012 by a group of experts from the study hospital. As appropriate, descriptive statistics and multivariate, multilevel models were used to compare the two groups and to explore the association between delirium occurrence and the selected outcomes. RESULTS Twelve percent of the 1608 historical controls and 20% of the 1684 postintervention patients were diagnosed with delirium according to the ICD-10 delirium diagnosis codes. Patients being treated for heart disease, and those with septic shock, ARDS, renal insufficiency (acute or chronic), older age and higher numbers of comorbidities were significantly more likely to develop delirium during their stay. Multivariate models comparing the historical controls with the post intervention group indicated significant differences in delirium period prevalence (odds ratio 1.68, 95% confidence interval [CI] 1.38–2.06; p <0.001), length of stay in the ICU (time ratio [TR] 0.94, CI 0.89–1.00; p = 0.048), cost per case (median difference 3.83, CI 0.54–7.11; p = 0.023) and duration of mechanical ventilation (TR 0.84, CI 0.77–0.92; p <0.001). The observed differences in the other four outcomes – in-hospital mortality, delirium duration, length of stay in the hospital, and nursing hours per case – were not significant. Delirium was a significant predictor for prolonged duration of mechanical ventilation and for both ICU and hospital stay. CONCLUSION Standardised delirium management, specifically delirium screening, supports timely detection of delirium in ICU patients. Increased awareness of delirium after the implementation of standardised multiprofessional, multicomponent management leads to increased therapeutic attention, a prolongation of ICU stay and increased costs, but with no influence on mortality

A hospital-wide evaluation of delirium prevalence and outcomes in acute care patients : a cohort study

Background: Delirium is a well-known complication in cardiac surgery and intensive care unit (ICU) patients. However, in many other settings its prevalence and clinical consequences are understudied. The aims of this study were: (1) To assess delirium prevalence in a large, diverse cohort of acute care patients classified as either at risk or not at risk for delirium; (2) To compare these two groups according to defined indicators; and (3) To compare delirious with non-delirious patients regarding hospital mortality, ICU and hospital length of stay, nursing hours and cost per case. Methods: This cohort study was performed in a Swiss university hospital following implementation of a delirium management guideline. After excluding patients aged < 18 years or with a length of stay (LOS) < 1 day, 29′278 patients hospitalized in the study hospital in 2014 were included. Delirium period prevalence was calculated based on a Delirium Observation Scale (DOS) score ≥ 3 and / or Intensive Care Delirium Screening Checklist (ICDSC) scores ≥4. Results: Of 10′906 patients admitted, DOS / ICDSC scores indicated delirium in 28.4%. Delirium was most prevalent (36.2–40.5%) in cardiac surgery, neurosurgery, trauma, radiotherapy and neurology patients. It was also common in geriatrics, internal medicine, visceral surgery, reconstructive plastic surgery and cranio-maxillo-facial surgery patients (prevalence 21.6–28.6%). In the unadjusted and adjusted models, delirious patients had a significantly higher risk of inpatient mortality, stayed significantly longer in the ICU and hospital, needed significantly more nursing hours and generated significantly higher costs per case. For the seven most common ICD-10 diagnoses, each diagnostic group’s delirious patients had worse outcomes compared to those with no delirium. Conclusions: The results indicate a high number of patients at risk for delirium, with high delirium prevalence across all patient groups. Delirious patients showed significantly worse clinical outcomes and generated higher costs. Subgroup analyses highlighted striking variations in delirium period-prevalence across patient groups. Due to the high prevalence of delirium in patients treated in care centers for radiotherapy, visceral surgery, reconstructive plastic surgery, cranio-maxillofacial surgery and oral surgery, it is recommended to expand the current focus of delirium management to these patient groups

5G Visualization: The METIS-II Project Approach

[EN] One of the main objectives of the METIS-II project was to enable 5G concepts to reach and convince a wide audience from technology experts to decision makers from non-ICT industries. To achieve this objective, it was necessary to provide easy-to-understand and insightful visualization of 5G. This paper presents the visualization platform developed in the METIS-II project as a joint work of researchers and artists, which is a 3D visualization tool that allows viewers to interact with 5G-enabled scenarios, while permitting simulation driven data to be intuitively evaluated. The platform is a game-based customizable tool that allows a rapid integration of new concepts, allows real-time interaction with remote 5G simulators, and provides a virtual reality-based immersive user experience. As a result, the METIS-II visualization platform has successfully contributed to the dissemination of 5G in different fora and its use will be continued after METIS-II.This work has been performed in the framework of the H2020/5G-PPP project METIS-II cofunded by the EU. The authors wish to thank the rest of METIS-II colleagues who contributed to the development of the METIS-II visualization platform.Martín-Sacristán, D.; Herranz Claveras, C.; Monserrat Del Río, JF.; Szczygiel, A.; Kuruvatti, NP.; Garcia-Roger, D.; Prado-Alvarez, D.... (2018). 5G Visualization: The METIS-II Project Approach. Mobile Information Systems. 1-8. https://doi.org/10.1155/2018/2084950S18Zyda, M. (2005). From visual simulation to virtual reality to games. Computer, 38(9), 25-32. doi:10.1109/mc.2005.297Johnson, C. (2004). Top scientific visualization research problems. IEEE Computer Graphics and Applications, 24(4), 13-17. doi:10.1109/mcg.2004.20Tullberg, H., Popovski, P., Li, Z., Uusitalo, M. A., Hoglund, A., Bulakci, O., … Monserrat, J. F. (2016). The METIS 5G System Concept: Meeting the 5G Requirements. IEEE Communications Magazine, 54(12), 132-139. doi:10.1109/mcom.2016.1500799cmLee, B., Riche, N. H., Isenberg, P., & Carpendale, S. (2015). More Than Telling a Story: Transforming Data into Visually Shared Stories. IEEE Computer Graphics and Applications, 35(5), 84-90. doi:10.1109/mcg.2015.99Yi, J. S., Kang, Y. ah, & Stasko, J. (2007). Toward a Deeper Understanding of the Role of Interaction in Information Visualization. IEEE Transactions on Visualization and Computer Graphics, 13(6), 1224-1231. doi:10.1109/tvcg.2007.70515Campbell, B. D. (2016). Immersive Visualization to Support Scientific Insight. IEEE Computer Graphics and Applications, 36(3), 17-21. doi:10.1109/mcg.2016.6